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Woman with natural, radiant skin

Your Skin Is More Capable
Than Your Skincare.

Powered by the skin's own renewal biology.

U.S. Patents No. 11,491,096 and 11,020,452

What makes DefenAge different

Your skin holds a reserve of dormant cells, younger and less damaged than the ones on the surface. They have always been there.

Age-Repair Defensins® signal those dormant cells to become active. The same biological pathway the body uses during wound healing. No injury required.

30+ Clinical studies on Defensin technology and DefenAge products
28 Awards from the most trusted voices in beauty
10,000+ ★★★★★ Five-star reviews from verified buyers
As featured in Allure, GQ Daily, People, Good Housekeeping, Dermatology Times, NewBeauty

The Science Behind Skin Renewal

Any time you get a cut or a scrape, your body's natural wound-healing process kicks into high gear. It stimulates cellular regeneration to create fresh, healthy cells, which is why the new skin that appears looks firmer and smoother than the surrounding skin.

Thanks to the discovery of a molecule called Defensins, regenerative medicine doctors found a way to bottle up this process to deliver the same sort of fresh, baby-soft skin without any actual wound required. Their research led to a visionary new strategy for anti-aging and the eventual creation of DefenAge, an award-winning skincare line known for its transformational results.

Journal of Drugs in Dermatology, 2018, 17(4):426-441

That research led to DefenAge, the only skincare line built on patented Age-Repair Defensins® technology, supported by 30+ clinical studies and developed in collaboration with board-certified dermatologists.

Defensin signaling mechanism
The biology

Why DefenAge is different

Defensins work by targeting the renewal cells the body holds in reserve, the same ones that build new young skin during healing. Supporting those cells is the foundation of the DefenAge approach.

What changes with age

The signal quiets. The ability remains.

The skin is still capable of renewing itself. What diminishes over time is the trigger. Defensins support that signal directly.

"The skin hasn't lost its ability to renew. It's lost the signal to start. That changes the whole conversation about what we should be reaching for."

Dr. Jessica Weiser, Board-Certified Dermatologist, Weiser Skin MD, New York

Experience DefenAge

The DefenAge core regimen is three products. The 8-in-1 BioSerum, the 24/7 Barrier Balance Cream, and the 2-Minute Reveal Exfoliating Mask work together to deliver the full renewal signal morning and evening.

First meaningful results typically appear within one to two weeks. You've already seen this biology at work. When a wound heals, the body activates dormant cells to produce new, younger-looking skin in a matter of days. Defensins were inspired by that same biological process. Two weeks is often enough time to begin experiencing what this technology can do for your skin.

The Fly Kit is a two-week introduction to the DefenAge regimen, housed in a cosmetic bag. Everything you need to experience Age-Repair Defensins® technology for yourself.

01 Morning + Evening

8-in-1 BioSerum

A Defensin concentrate. Applied morning and evening, it delivers Alpha-Defensin 5 and Beta-Defensin 3, which support the skin's renewal signaling process.

02 Daily Moisturizer

24/7 Barrier Balance Cream

A daily moisturizer formulated to work alongside the serum. Rich and nourishing without feeling heavy.

03 2–3× Per Week

2-Minute Reveal Exfoliating Mask

Used two to three times a week. Gently removes dead cells from the skin surface, revealing younger-looking skin and allowing the renewal process to show through more visibly.

Fly Kit · Housed in a slick cosmetic bag

DefenAge's core skincare regimen

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Exclusive offer

Experience DefenAge.
A two-week introduction to Age-Repair Defensins® technology.

DefenAge Fly Kit
$29 $98

You save $69 · 70% off regular price

Code at checkout: SUMMER29

Available while supplies last

Try the Fly Kit for $29

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